Ebola virus glycoproteins induce global surface protein down-modulation and loss of cell adherence.

@article{Simmons2002EbolaVG,
  title={Ebola virus glycoproteins induce global surface protein down-modulation and loss of cell adherence.},
  author={Graham Simmons and ROUVEN J. WOOL-LEWIS and Fr{\'e}d{\'e}ric Baribaud and Robert C Netter and Paul A. Bates},
  journal={Journal of virology},
  year={2002},
  volume={76 5},
  pages={2518-28}
}
The Ebola virus envelope glycoprotein (GP) derived from the pathogenic Zaire subtype mediates cell rounding and detachment from the extracellular matrix in 293T cells. In this study we provide evidence that GPs from the other pathogenic subtypes, Sudan and Côte d'Ivoire, as well as from Reston, a strain thought to be nonpathogenic in humans, also induced cell rounding, albeit at lower levels than Zaire GP. Sequential removal of regions of potential O-linked glycosylation at the C terminus of… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
97 Citations
53 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 97 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 53 references

Similar Papers

Loading similar papers…