Ebola virus glycoprotein GP is not cytotoxic when expressed constitutively at a moderate level.

@article{AlazardDany2006EbolaVG,
  title={Ebola virus glycoprotein GP is not cytotoxic when expressed constitutively at a moderate level.},
  author={Nathalie Alazard-Dany and Valentina A. Volchkova and Olivier Reynard and Caroline Carbonnelle and Olga Dolnik and Mich{\`e}le Ottmann and Alexander A Khromykh and Viktor E. Volchkov},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 5},
  pages={1247-57}
}
Transient expression of Ebola virus (EBOV) glycoprotein GP causes downregulation of surface proteins, cell rounding and detachment, a phenomenon believed to play a central role in the pathogenicity of the virus. In this study, evidence that moderate expression of GP does not result in such morphological changes was provided. It was shown that GP continuously produced in 293T cells from the Kunjin virus replicon was correctly processed and transported to the plasma membrane without affecting the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 32 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Similar Papers

Loading similar papers…