Ebola virus VP30-mediated transcription is regulated by RNA secondary structure formation.

@article{Weik2002EbolaVV,
  title={Ebola virus VP30-mediated transcription is regulated by RNA secondary structure formation.},
  author={Michael Weik and Jens Modrof and H -D Klenk and Stephan Becker and Elke M{\"u}hlberger},
  journal={Journal of virology},
  year={2002},
  volume={76 17},
  pages={8532-9}
}
The nucleocapsid protein VP30 of Ebola virus (EBOV), a member of the Filovirus family, is known to act as a transcription activator. By using a reconstituted minigenome system, the role of VP30 during transcription was investigated. We could show that VP30-mediated transcription activation is dependent on formation of a stem-loop structure at the first gene start site. Destruction of this secondary structure led to VP30-independent transcription. Analysis of the transcription products of… CONTINUE READING
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