Ebola hemorrhagic fever: evaluation of passive immunotherapy in nonhuman primates.

@article{Jahrling2007EbolaHF,
  title={Ebola hemorrhagic fever: evaluation of passive immunotherapy in nonhuman primates.},
  author={Peter B Jahrling and Thomas W Geisbert and James R Swearengen and Thomas C. Larsen and Thomas W. Geisbert},
  journal={The Journal of infectious diseases},
  year={2007},
  volume={196 Suppl 2},
  pages={S400-3}
}
The survival of 7 of 8 patients with Ebola virus (EBOV) infection after transfusions of convalescent-phase blood during a 1995 outbreak of EBOV infection is frequently cited as evidence that passive immunotherapy is a viable treatment option. To test whether whole-blood transfusions were more efficacious than passively administered immunoglobulins or monoclonal antibodies, we transfused convalescent-phase blood from EBOV-immune monkeys into naive animals shortly after challenge with EBOV… CONTINUE READING