Ebola Virus Disease Diagnostics, Sierra Leone: Analysis of Real-time Reverse Transcription-Polymerase Chain Reaction Values for Clinical Blood and Oral Swab Specimens.

@article{Erickson2016EbolaVD,
  title={Ebola Virus Disease Diagnostics, Sierra Leone: Analysis of Real-time Reverse Transcription-Polymerase Chain Reaction Values for Clinical Blood and Oral Swab Specimens.},
  author={Bobbie Rae Erickson and Tara K. Sealy and Tim Flietstra and Laura Michelle Morgan and Brima Kargbo and Victor E. Matt-Lebby and Aridth Gibbons and Ayan K. Chakrabarti and J. Michael Graziano and Lance Presser and Mike Flint and Brian Healy Bird and Shelley C Brown and John David Klena and Dianna M. Blau and Aaron C Brault and Jessica A. Belser and Johanna S. Salzer and Amy J Schuh and Michael K Lo and Marko Zivcec and Rachael A. Priestley and Meredith J. Pyle and Christin H. Goodman and Scott W. Bearden and Brian R. Amman and Alison Jane Basile and {\'E}ric Bergeron and Michael D. Bowen and Kimberly Anne Dodd and Molly Freeman and Laura K McMullan and Christopher D Paddock and Brandy J. Russell and A. J. Casal S{\'a}nchez and Jonathan S Towner and David Wang and Galina E. Zemtsova and Robyn Anne Stoddard and Maryann A. Turnsek and Lisa Wiggleton Guerrero and Shannon L. Emery and Janae L. Stovall and Markus H. Kainulainen and Jamie L. Perniciaro and Slavica Mijatovic-Rustempasic and Gulchekhra Shakirova and J{\"o}rn Winter and Christopher Sexton and Feng Liu and Kimetha Slater and Raydel Anderson and Lauren E. Andersen and Cheng-Feng Chiang and Wen-Pin Tzeng and Samuel James Crowe and Matthew J. Maenner and Christina F Spiropoulou and Stuart T. Nichol and Ute Stroeher},
  journal={The Journal of infectious diseases},
  year={2016},
  volume={214 suppl 3},
  pages={
          S258-S262
        }
}
During the Ebola virus outbreak of 2013-2016, the Viral Special Pathogens Branch field laboratory in Sierra Leone tested approximately 26 000 specimens between August 2014 and October 2015. Analysis of the B2M endogenous control Ct values showed its utility in monitoring specimen quality, comparing results with different specimen types, and interpretation of results. For live patients, blood is the most sensitive specimen type and oral swabs have little diagnostic utility. However, swabs are… CONTINUE READING
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