Ebola--a growing threat?

  title={Ebola--a growing threat?},
  author={Heinz Feldmann},
  journal={The New England journal of medicine},
  volume={371 15},
  • H. Feldmann
  • Published 2014
  • Medicine
  • The New England journal of medicine
The latest outbreak of ebolavirus in West Africa has demonstrated our public health systems' limited ability to respond to rare, highly virulent communicable diseases. Despite years of research on ebolavirus and marburgvirus, we have no vaccines or treatments available. 
Ebola Virus Disease: A Perspective for the United States.
This article reviews the etiology, pathogenesis, transmission, clinical manifestations, diagnosis, treatment, and prevention of the disease with emphasis on the identification and management in the US. Expand
Chapter 28 – Filoviruses
Filoviruses are thought to be zoonoses with strong circumstantial evidence that bats are the animal reservoirs, and the replication strategy of the negative sense single-stranded RNA genome has much in common with paramyxovirus and rhabdovirus. Expand
Ebola--underscoring the global disparities in health care resources.
  • A. Fauci
  • Medicine
  • The New England journal of medicine
  • 2014
An outbreak of Ebola virus disease has jolted West Africa, claiming more than 1000 lives. As the disease's spread gains attention, health professionals and the public struggle to comprehend theExpand
Field-deployable, quantitative, rapid identification of active Ebola virus infection in unprocessed blood† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc03281a
The West African Ebola virus outbreak underlined the importance of delivering mass diagnostic capability outside the clinical or primary care setting.
Clinical Manifestations and Laboratory Diagnosis of Ebola Virus Infection
This chapter highlights the clinical features of Ebola virus disease and findings on laboratory tests and the precautionary guidelines set up by Center for Disease Control and Prevention in regards to proper usage of personal protective gear and handling of biological specimens of Ebola disease patients. Expand
Emerging Viral Diseases: Confronting Threats with New Technologies
Emerging viral diseases continue to threaten human health, but recent scientific advances are better positioning us to treat them and to detect and control the causative pathogens. Emerging viralExpand
Aerosol Transmission of Filoviruses
This review deals with the controversial issue of aerosol transmission of filoviruses, which is believed to be the source of ebolaviruses for human index case(s) in most outbreaks. Expand
Ecology of Ebolavirus: A Review of Current Knowledge, Speculations and Future Research Directions
Recent findings suggest that outbreaks of Ebola virus might not just be sporadic as previously thought, but could be linked to changes in ecology that brought humans in close proximity to natural / primary host and immediate hosts of Ebolairus due to human exploitation of previously unoccupied forest ecosystems. Expand
Epidemiology and Immunopathogenesis of Ebola and Flaviviruses
T cell analysis demonstrated that individuals mount sustained specific and cross-reactive responses to nonstructural protein 3 (NS3) during the acute and late convalescent phases and development of a T cell diagnostic based on responses to NS3 distinguishes human infections by African ZIKV and DENV. Expand
Emerging Therapeutic Approaches to Combat the Pandemicity of the Deadly Ebola Virus
Post-exposure interventions are therefore necessary for the treatment of cases as they occur, and mass immunization is unlikely due to the localized and sporadic nature of EBOV infections. Expand


Emergence of Zaire Ebola virus disease in Guinea.
Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known E BOV strains from the Democratic Republic of Congo and Gabon. Expand
Possible leap ahead in filovirus therapeutics
A novel synthetic adenosine analogue, BCX4430, a synthetic drug-like small molecule that provides protection from Ebola and Marburg virus infection in animal models is described. Expand
Ebola haemorrhagic fever
Ebola virus infections are characterised by immune suppression and a systemic inflammatory response that causes impairment of the vascular, coagulation, and immune systems, leading to multiorgan failure and shock, and thus, in some ways, resembling septic shock. Expand
Potential Vaccines and Post-Exposure Treatments for Filovirus Infections
Current progress in the development of filovirus therapeutics and vaccines is outlined herein with respect to their current level of testing, evaluation, and proximity toward human implementation, specifically with regard to human clinical trials, nonhuman primate studies, small animal studies, and in vitro development. Expand
Isolation of Genetically Diverse Marburg Viruses from Egyptian Fruit Bats
Data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans. Expand
For personal use only. No other uses without permission. Copyright © 2014 Massachusetts Medical Society
  • The New England Journal of Medicine Downloaded from nejm.org at UNIVERSITY OF GRONINGEN on August
  • 2014
April 15 (Epub ahead of print)
  • April 15 (Epub ahead of print)
DOI: 10.1056/NEJMoa1404505
  • DOI: 10.1056/NEJMoa1404505
DOI: 10.1056/NEJMp1405314 Copyright © 2014 Massachusetts Medical Society
  • DOI: 10.1056/NEJMp1405314 Copyright © 2014 Massachusetts Medical Society