Eating disorders and depression: Is there a serotonin connection?

  title={Eating disorders and depression: Is there a serotonin connection?},
  author={David C. Jimerson and Michael D. Lesem and Walter H. Kaye and Arlene P. Hegg and Timothy D. Brewerton},
  journal={Biological Psychiatry},
Persistent Alterations in Behavior and Serotonin Activity after Recovery from Anorexia and Bulimia Nervosa a
  • W. Kaye
  • Psychology
    Annals of the New York Academy of Sciences
  • 1997
Whether a disturbance of serotonin activity contributes to the psychopathology of eating disorders and whether such alterations are stateor trait-related is focused on.
The Role of Neurotransmitter Systems in Eating and Substance Use Disorders
Overall, research suggests that 5-HT and DA are involved in the neurobiology ED and SUD as well as behavioral addictions, and comparative research across disorders should be undertaken to identify underlying mechanisms.
Serotonin alterations in anorexia and bulimia nervosa: New insights from imaging studies
Serotonin activity in anorexia nervosa after long-term weight restoration: response to D-fenfluramine challenge.
The results suggest that abnormalities in 5HT activity do not contribute significantly to trait status in anorexia nervosa and there was no difference between long-term weight-restored anorexics and controls in their endocrine response to D-fenfluramine.
Serotonin Function Following Remission from Bulimia Nervosa
Eating disorders: clinical features and pathophysiology
Symptomatic relapse in bulimia nervosa following acute tryptophan depletion.
The results suggest that diminished serotonin activity may trigger some of the cognitive and mood disturbances associated with BN, and support suggestions that chronic depletion of plasma tryptophan may be one of the mechanisms whereby persistent dieting can lead to the development of eating disorders in vulnerable individuals.
The relationship of the platelet 5-HT-induced calcium response to clinical symptoms in eating disorders
The relationship between the 5-HT-induced calcium response in platelets and the clinical symptoms was focused on and there was an enhanced response in patients with bulimic symptoms or other impulsive behaviors.
5-HT 2A Receptors in Eating Disorders
The gene coding for 5-HT2A receptor was the very first gene associated with eating disorders, mainly in anorexia nervosa, raising the scientific interest in the serotonin pathway to explain their genetic vulnerability.


Evidence for Altered Serotonin Function in Bulimia and Anorexia Nervosa: Behavioral Implications
The relationship between the eating disorders bulimia nervosa and anorexia nervosa has been under scrutiny as increasing clinical information about these syndromes has emerged. The DSM-III-R
Are anorexia nervosa and bulimia variants of affective disorders?
There exists a growing tendency to view anorexia nervosa and bulimia as special forms of depressive illness, but there is more evidence that the aforementioned association--whatever its real nature--prevails more clearly in a subgroup of bulimic patients.
The relationship between affective disorder and eating disorders: a review of the literature.
It is recommended that future research in this area attempt to identify subpopulations of patients with affective disorder and eating disorders by means of a longitudinal, multilevel strategy with serial determinations.
Bulimia and Depression
This report describes the results of semistructured interviews using the Schedule for Affective Disorders and Schizophrenia to evaluate the frequency of the current and lifetime diagnoses of affective illness among 50 female patients meeting DSM‐III criteria for bulimia.
CSF monoamine levels in normal-weight bulimia: evidence for abnormal noradrenergic activity.
The lower CSF norepinephrine concentration suggests bulimia is not simply a variant of affective disorders, and monoaminergic disturbances are part of this disorder's neurobiological syndrome.
Hypothalamic serotonin: pharmacological, biochemical, and behavioral analyses of its feeding-suppressive action.
While this review focuses on the indoleamine, serotonin, with respect to its effects after peripheral and central administration, attention is also given to the catecholamines, which are believed to interact with serotonin in the complex process of controlling eating patterns and appetite for specific macronutrients.
Affective Disturbance in Eating Disorders
It was found that a large group with bulimia and restrictive anorexia nervosa was subject to a depressive disorder and a high incidence of dexamethasone nonsuppression was found to be related to various measures of depression.
Major Affective Disorder in Anorexia Nervosa and Bulimia
It was found that 44.2% of patients with a lifetime history of anorexia nervosa or bulimia had a lifetime diagnosis of DSM-III major affective disorder, with abstaining anorectics having a lower rate of depression than those with bulimic symptoms.
Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior.
It is suggested that reduced central serotonergic function is present in a subgroup of patients with major affective and/or personality disorder and is associated with history of suicide attempt in patients with either disorder, but with impulsive aggression in Patients with personality disorder only.
Serotonergic function in depression. Prolactin response to intravenous tryptophan in depressed patients and healthy subjects.
There was a marked blunting of the maximal prolactin response to the tryptophan in both the male and female patients, providing strong support for a possible serotonergic abnormality in depression.