Eating disorder predisposition is associated with ESRRA and HDAC4 mutations.

  title={Eating disorder predisposition is associated with ESRRA and HDAC4 mutations.},
  author={Huxing Cui and Jarrette Moore and Sunbola S Ashimi and Brittany L. Mason and Jordan N Drawbridge and Shizhong Han and Benjamin Hing and Abigail Matthews and Carrie J. McAdams and Benjamin W. Darbro and Andrew A Pieper and D. A. Waller and Chao Xing and Michael Lutter},
  journal={The Journal of clinical investigation},
  volume={123 11},
Anorexia nervosa and bulimia nervosa are common and severe eating disorders (EDs) of unknown etiology. Although genetic factors have been implicated in the psychopathology of EDs, a clear biological pathway has not been delineated. DNA from two large families affected by EDs was collected, and mutations segregating with illness were identified by whole-genome sequencing following linkage mapping or by whole-exome sequencing. In the first family, analysis of twenty members across three… CONTINUE READING
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