Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.
@article{Cangiano1992EatingBA, title={Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.}, author={Carlo Cangiano and Fabrizio Ceci and Antonia Cascino and Maria del Ben and Alessandro Laviano and Maurizio Muscaritoli and Fabiola Antonucci and Filippo Rossi‐Fanelli}, journal={The American journal of clinical nutrition}, year={1992}, volume={56 5}, pages={ 863-7 } }
Previous observations have shown that oral administration of 5-hydroxytryptophan (5-HTP) without dietary prescriptions causes anorexia, decreased food intake, and weight loss in obese subjects. To confirm these data over a longer period of observation and to verify whether adherence to dietary restriction could be improved by 5-HTP, 20 obese patients were randomly assigned to receive either 5-HTP (900 mg/d) or a placebo. The study was double-blinded and was for two consecutive 6-wk periods. No…
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References
SHOWING 1-10 OF 22 REFERENCES
Carbohydrate craving in obese people: Suppression by treatments affecting serotoninergic transmission
- Medicine
- 1981
Observations show that some obese people do consume carbohydrate-rich snacks frequently and preferentially, and that this behavior can sometimes be diminished by treatments thought to enhance serotonin's release (fenfluramine) or synthesis (tryptophan).
Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity.
- Medicine, BiologyDrugs
- 1975
The majority of patients tolerate fenfluramine satisfactorily, although some patients may have to discontinue the drug because of troublesome gastro-intestinal problems, diarrhoea, drowsiness or dizziness, and it probably has little abuse potential.
A double-blind, placebo-controlled trial of fluoxetine plus behavior modification in the treatment of obese binge-eaters and non-binge-eaters.
- Psychology, MedicineThe American journal of psychiatry
- 1990
Patients treated with fluoxetine plus behavior modification lost significantly more weight than those treated with placebo plusbehavior modification, however, the drug did not appear to have a differential benefit for binge-eaters.
Medial hypothalamic serotonin: role in circadian patterns of feeding and macronutrient selection
- BiologyBrain Research
- 1989
Selective increase in carbohydrate intake by rats treated with 8-hydroxy-2-(di-n-propylamino)-tetraline or buspirone.
- Biology, ChemistryLife sciences
- 1990
Fenfluramine and fluoxetine spare protein consumption while suppressing caloric intake by rats.
- Biology, MedicineScience
- 1977
Observations indicate that two distinct brain mechanisms, sensitive to different drugs, underlie the elective consumption of protein and calories.
Plasma tryptophan and anorexia in human cancer.
- Medicine, PsychologyEuropean journal of cancer & clinical oncology
- 1986
Serotonin and Appetite
- BiologyAnnals of the New York Academy of Sciences
- 1990
5-HT1A agonists (8-OHDPAT, buspirone, gepirone, etc.) stimulate intake in freely feeding rats, probably by activating autoreceptors on the cell bodies of 5- HT neurons so that 5-HT release at terminals is decreased and feeding in previously food-deprived rats is decreased.
The effect of 5‐hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine
- Biology, PsychologyThe Journal of pharmacy and pharmacology
- 1975
Findings provide further evidence for the role of 5‐hydroxytryptamine (5‐HT), in the anorexic effect of fenfluramine, and suggest that a 5‐HT mechanism, inhibitory for feeding, produces particularly severe suppression of food intake in rats with lateral hypothalamic lesions.