Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.

  title={Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan.},
  author={Carlo Cangiano and Fabrizio Ceci and Antonia Cascino and Maria del Ben and Alessandro Laviano and Maurizio Muscaritoli and Fabiola Antonucci and Filippo Rossi‐Fanelli},
  journal={The American journal of clinical nutrition},
  volume={56 5},
Previous observations have shown that oral administration of 5-hydroxytryptophan (5-HTP) without dietary prescriptions causes anorexia, decreased food intake, and weight loss in obese subjects. To confirm these data over a longer period of observation and to verify whether adherence to dietary restriction could be improved by 5-HTP, 20 obese patients were randomly assigned to receive either 5-HTP (900 mg/d) or a placebo. The study was double-blinded and was for two consecutive 6-wk periods. No… 

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Serotonin and Appetite

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    Annals of the New York Academy of Sciences
  • 1990
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The effect of 5‐hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine

Findings provide further evidence for the role of 5‐hydroxytryptamine (5‐HT), in the anorexic effect of fenfluramine, and suggest that a 5‐HT mechanism, inhibitory for feeding, produces particularly severe suppression of food intake in rats with lateral hypothalamic lesions.