Eating Disturbance in Behavioural-Variant Frontotemporal Dementia

@article{Piguet2011EatingDI,
  title={Eating Disturbance in Behavioural-Variant Frontotemporal Dementia},
  author={Olivier Piguet},
  journal={Journal of Molecular Neuroscience},
  year={2011},
  volume={45},
  pages={589-593}
}
  • O. Piguet
  • Published 17 May 2011
  • Psychology, Medicine
  • Journal of Molecular Neuroscience
Behavioural-variant frontotemporal dementia (bvFTD) is a progressive neurodegenerative brain disorder, clinically characterised by changes in cognition, personality and behaviour. Marked disturbances in eating behaviour, such as overeating and preference for sweet foods, are also commonly reported. This paper reviews the current literature on eating abnormalities in bvFTD, their clinical characteristics and biological correlates, and the contribution of hypothalamus to eating regulation… 
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34 Citations

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In this review, evidence is summarized regarding four areas: eating and body weight alterations in FTD, the most common assessment methods, anatomical correlates of eating disorders, and finally, proposed underlying mechanisms.

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While symptomatic treatments are likely to remain important behavior management tools, targeting the underlying pathology of bvFTD with disease-modifying agents will hopefully be the future of treatment.

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The clinical features, diagnostic criteria, pathology, genetics, and therapeutic interventions for FTD spectrum disorders are reviewed.

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Given the paucity of effective treatments for these symptoms, it is highlighted how contributing mechanisms delineated in cognitive neuroscience may inform future approaches to clinical trials and more precise symptomatic treatments for FTDs.

Frontotemporal dementia.

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TLDR
It is proposed that largely due to the paucity of biomarkers for primary psychiatric disorders, and the limited use of FTLD-related biomarkers by psychiatrists at present, it is very difficult to separate patients with early bvFTD from those withPrimary psychiatric disorders based on clinical grounds.

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Patients with bvFTD patients had lower hypothalamic volumes compared with controls, and different genetic mutations may have a differential impact on the hypothalamus.

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The literature on eating behavior and swallow impairments (dysphagia) in each of the syndromes caused by Frontotemporal lobar degeneration is reviewed and summarized.

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TLDR
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TLDR
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TLDR
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