Eating Disturbance in Behavioural-Variant Frontotemporal Dementia

@article{Piguet2011EatingDI,
  title={Eating Disturbance in Behavioural-Variant Frontotemporal Dementia},
  author={Olivier Piguet},
  journal={Journal of Molecular Neuroscience},
  year={2011},
  volume={45},
  pages={589-593}
}
  • O. Piguet
  • Published 17 May 2011
  • Psychology, Medicine
  • Journal of Molecular Neuroscience
Behavioural-variant frontotemporal dementia (bvFTD) is a progressive neurodegenerative brain disorder, clinically characterised by changes in cognition, personality and behaviour. Marked disturbances in eating behaviour, such as overeating and preference for sweet foods, are also commonly reported. This paper reviews the current literature on eating abnormalities in bvFTD, their clinical characteristics and biological correlates, and the contribution of hypothalamus to eating regulation… 
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34 Citations

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The clinical features, diagnostic criteria, pathology, genetics, and therapeutic interventions for FTD spectrum disorders are reviewed.
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It is proposed that largely due to the paucity of biomarkers for primary psychiatric disorders, and the limited use of FTLD-related biomarkers by psychiatrists at present, it is very difficult to separate patients with early bvFTD from those withPrimary psychiatric disorders based on clinical grounds.
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The literature on eating behavior and swallow impairments (dysphagia) in each of the syndromes caused by Frontotemporal lobar degeneration is reviewed and summarized.
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References

SHOWING 1-10 OF 40 REFERENCES
Eating and hypothalamus changes in behavioral-variant frontotemporal dementia
TLDR
This study aimed to address the issue of hypothalamus role in feeding regulation in Behavioral‐variant frontotemporal dementia using 2 complementary approaches.
Characteristics of abnormal eating behaviours in frontotemporal lobar degeneration: a cross-cultural survey
TLDR
The aims of this study were to investigate changes in eating behaviours in Japanese FTLD and AD patients and to compare the profile of abnormal eating behaviour in Japanese and Western patients using the same data.
Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia
TLDR
Binge eating can occur despite reported satiety and is associated with damage to a right-sided orbitofrontal-insular-striatal circuit in humans, supporting a model in which ventral insular and orbitof prefrontal cortices serve as higher-order gustatory regions and cooperate with the striatum to guide appropriate feeding responses.
Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management
Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer’s disease
TLDR
It is likely that the changing in eating behaviours reflects the involvement of a common network in both variants of frontotemporal dementia—namely, the ventral (orbitobasal) frontal lobe, temporal pole, and amygdala.
VBM signatures of abnormal eating behaviours in frontotemporal lobar degeneration
Neuroanatomical correlates of behavioural disorders in dementia.
TLDR
The findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions and highlight the importance of distinct regions on the medial wall of the right frontal lobe in regulating different behaviours.
The utility of the Cambridge Behavioural Inventory in neurodegenerative disease
TLDR
The CBI is a robust, easy-to-use and valid instrument, which has the capacity to discriminate between neurodegenerative diseases, and may be of value in monitoring therapeutic interventions.
The Neuropsychiatric Inventory
TLDR
The NPI has the advantages of evaluating a wider range of psychopathology than existing instruments, soliciting information that may distinguish among different etiologies of dementia, differentiating between severity and frequency of behavioral changes, and minimizing administration time.
Hypothalamic–endocrine aspects in Huntington's disease
TLDR
Investigating neuroendocrine changes in HD opens up the possibility of finding biomarkers to evaluate future therapies for HD, as well as of identifying novel targets for therapeutic interventions.
...
...