Eating, exercise, and "thrifty" genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases.
@article{Chakravarthy2004EatingEA, title={Eating, exercise, and "thrifty" genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases.}, author={M. Chakravarthy and F. Booth}, journal={Journal of applied physiology}, year={2004}, volume={96 1}, pages={ 3-10 } }
Survival of Homo sapiens during evolution was dependent on the procurement of food, which in turn was dependent on physical activity. However, food supply was never consistent. Thus it is contended that the ancient hunter-gatherer had cycles of feast and famine, punctuated with obligate periods of physical activity and rest. Hence, gene selection in the Late-Paleolithic era was probably influenced by physical activity and rest. To ensure survival during periods of famine, certain genes evolved… CONTINUE READING
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- 2013
- 115
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- 50
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References
SHOWING 1-10 OF 58 REFERENCES
Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy.
- Medicine
- Journal of applied physiology
- 2002
- 418
- PDF
Physical activity, energy expenditure and fitness: an evolutionary perspective.
- Biology, Medicine
- International journal of sports medicine
- 1998
- 251
- Highly Influential
Stone Agers in the Fast Lane: Chronic Degenerative Diseases in Evolutionary Perspective
- Medicine
- 1988
- 186
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?
- Biology, Medicine
- American journal of human genetics
- 1962
- 3,052
- Highly Influential
- PDF
J.B. Wolffe Memorial Lecture. "Why exercise?".
- Medicine
- Medicine and science in sports and exercise
- 1992
- 78
Effects of 3 days of "postoperative" low caloric feeding with or without bed rest on insulin sensitivity in healthy subjects.
- Medicine
- Clinical nutrition
- 2003
- 43
Exercise training increases lipid metabolism gene expression in human skeletal muscle.
- Biology, Medicine
- American journal of physiology. Endocrinology and metabolism
- 2002
- 273
- PDF
Fasting activates the gene expression of UCP3 independent of genes necessary for lipid transport and oxidation in skeletal muscle.
- Biology, Medicine
- Biochemical and biophysical research communications
- 2002
- 38