Eat Me or Die

@article{Savill2003EatMO,
  title={Eat Me or Die},
  author={John Savill and Chris Gregory and Christopher Haslett},
  journal={Science},
  year={2003},
  volume={302},
  pages={1516 - 1517}
}
During embryonic development, the sculpting of many tissues depends on waves of apoptotic cell death among different cell populations. Unfortunately, at least in higher animals with sophisticated immune systems, dying cells must be engulfed by phagocytes to prevent a massive autoimmune response. In their Perspective, [ Savill et al .][1] discuss new work ([ Li et al .][2], [ Wang et al .][3]) that identifies a key receptor expressed by macrophages, PSR, that is essential for cell corpse… 
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References

SHOWING 1-10 OF 18 REFERENCES
Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences.
TLDR
The task is to understand and explain these diametrically opposed reactions to stimulation of the same receptors, which when microbial organisms or their products are engulfed via these receptors, inflammation results, and in many cases, acquired immunity is stimulated.
Phosphatidylserine Receptor Is Required for Clearance of Apoptotic Cells
TLDR
A critical role for PSR in early stages of mammalian organogenesis is demonstrated and it is suggested that this receptor may be involved in respiratory distress syndromes and congenital brain malformations.
Cell Corpse Engulfment Mediated by C. elegans Phosphatidylserine Receptor Through CED-5 and CED-12
TLDR
It is reported that psr-1, the Caenorhabditis elegans homolog of PSR, is important for cell corpse engulfment and suggests that PSR-1 is likely an upstream receptor for the signaling pathway containing CED-2, C ED-5,CED-10, and CED -12 proteins and plays an important role in recognizing phosphatidylserine during phagocytosis.
A blast from the past: clearance of apoptotic cells regulates immune responses
Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of
Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytes.
TLDR
The hitherto unrecognized existence of a feedback loop requiring soluble factors in addition to sFasL that may promote resolution of inflammation-phagocytic clearance of apoptotic cells leading to Fas-mediated killing of bystander leukocytes by phagocytizing macrophages is suggested.
Immunity
Cell
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