Eat, kill or die: when amoeba meets bacteria.

@article{Cosson2008EatKO,
  title={Eat, kill or die: when amoeba meets bacteria.},
  author={Pierre Cosson and Thierry Soldati},
  journal={Current opinion in microbiology},
  year={2008},
  volume={11 3},
  pages={271-6}
}
The core function of the innate immune response, phagocytosis, did not evolve first in metazoans but rather in primitive unicellular eukaryotes. Thus, though amoebae separated from the tree leading to metazoan shortly after the divergence of plants, they share many specific functions with mammalian phagocytic cells. Dictyostelium discoideum is by far the most studied amoeba, and it is proving useful to analyze phagocytosis and intracellular killing of bacteria. Since the basic mechanisms… CONTINUE READING

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