Easy and rapid differentiation of embryonic stem cells into functional motoneurons using sonic hedgehog-producing cells.

@article{Soundararajan2007EasyAR,
  title={Easy and rapid differentiation of embryonic stem cells into functional motoneurons using sonic hedgehog-producing cells.},
  author={Prabakaran Soundararajan and Benjamin W. Lindsey and Cindee Leopold and Victor F. Rafuse},
  journal={Stem cells},
  year={2007},
  volume={25 7},
  pages={1697-706}
}
Directing embryonic stem (ES) cells to differentiate into functional motoneurons has proven to be a strong technique for studying neuronal development as well as being a potential source of tissue for cell replacement therapies involving spinal cord disorders. Unfortunately, one of the mitogenic factors (i.e., sonic hedgehog agonist) used for directed differentiation is not readily available, and thus this technique has not been widely accessible. Here, we present a novel and simple method to… CONTINUE READING

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