Easily Accessible Mono- and Polytopic ­β-Cyclodextrin Hosts by Click Chemistry

@inproceedings{Mourer2008EasilyAM,
  title={Easily Accessible Mono- and Polytopic ­β-Cyclodextrin Hosts by Click Chemistry},
  author={Maxime Mourer and Fr{\'e}d{\'e}ric Hapiot and S{\'e}bastien Tilloy and Eric Monflier and St{\'e}phane Menuel},
  year={2008}
}
A great variety of mono- and polytopic β-cyclodextrin hosts have been easily synthesized by using the CuI-catalyzed azide–alkyne cycloaddition reaction. Of particular interest for their multibinding properties, dimeric and trimeric CD compounds were obtained by “clicking” mono-6-azido-β-cyclodextrin derivatives with flexible or rigid dialkynyl spacers. The reaction is general, high-yielding for some of the synthesized molecules (>80 %) and proceeds under mild conditions. (© Wiley-VCH Verlag… CONTINUE READING

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