Ease of DNA unwinding is a conserved property of yeast replication origins.

@article{Natale1993EaseOD,
  title={Ease of DNA unwinding is a conserved property of yeast replication origins.},
  author={Darren A. Natale and Robert M. Umek and David Kowalski},
  journal={Nucleic acids research},
  year={1993},
  volume={21 3},
  pages={
          555-60
        }
}
Autonomously replicating sequence (ARS) elements function as plasmid replication origins. Our studies of the H4 ARS and ARS307 have established the requirement for a DNA unwinding element (DUE), a broad easily-unwound sequence 3' to the essential consensus that likely facilitates opening of the origin. In this report, we examine the intrinsic ease of unwinding a variety of ARS elements using (1) a single-strand-specific nuclease to probe for DNA unwinding in a negatively-supercoiled plasmid… CONTINUE READING
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