Early years of biological agents therapy in Crohn's disease and risk of the human polyomavirus JC reactivation.

@article{Bellizzi2010EarlyYO,
  title={Early years of biological agents therapy in Crohn's disease and risk of the human polyomavirus JC reactivation.},
  author={Anna Bellizzi and Valentina Barucca and Daniela Fioriti and Maria Teresa Colosimo and Monica Mischitelli and Elena Anzivino and Fernanda Chiarini and Valeria Pietropaolo},
  journal={Journal of cellular physiology},
  year={2010},
  volume={224 2},
  pages={316-26}
}
Although the remarkable efficacy of biological therapy has resulted in significant success in inflammatory bowel disease (IBD) management, susceptibility to infections remains a concern. The biological agents include the tumor necrosis factor-alpha (TNF-alpha) inhibitors, for instance infliximab, and other immunomodulating agents, such as natalizumab. Progressive multifocal leukoencephalopathy (PML), a rare but mostly fatal opportunistic brain infection caused by reactivation of the human… CONTINUE READING
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