Early white-matter abnormalities of the ventral frontostriatal pathway in fragile X syndrome.

@article{Haas2009EarlyWA,
  title={Early white-matter abnormalities of the ventral frontostriatal pathway in fragile X syndrome.},
  author={Brian W. Haas and Naama Barnea-Goraly and Amy A. Lightbody and Swetapadma S Patnaik and Fumiko Hoeft and Heather Cody Hazlett and Joseph Piven and Allan L. Reiss},
  journal={Developmental medicine and child neurology},
  year={2009},
  volume={51 8},
  pages={593-9}
}
AIM Fragile X syndrome is associated with cognitive deficits in inhibitory control and with abnormal neuronal morphology and development. METHOD In this study, we used a diffusion tensor imaging (DTI) tractography approach to reconstruct white-matter fibers in the ventral frontostriatal pathway in young males with fragile X syndrome (n=17; mean age 2y 9mo, SD 7mo, range 1y 7mo-3y 10mo), and two age-matched comparison groups: (1) typically developing (n=13; mean age 2y 3mo, SD 7mo, range 1y… CONTINUE READING