Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-β in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats

@article{Wigg2004EarlyVE,
  title={Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-β in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats},
  author={Stefan Wigg and Marianne Tare and Jack C Forbes and Mark Emmanuel Cooper and Merlin C Thomas and Harold Arthur Coleman and Helena C Parkington and R. C. O’Brien},
  journal={Diabetologia},
  year={2004},
  volume={47},
  pages={1038-1046}
}
The impact of early vitamin E supplementation on vascular function in diabetes remains unresolved. Therefore, we examined the effects of vitamin E on functional and structural parameters and on chemical markers that are disturbed in diabetes in mesenteric and femoral arteries. Segments of both arteries, taken from control and 8-week-old streptozotocin diabetic Wistar rats that were treated or not with vitamin E, were mounted on wire and pressure myographs, after which endothelium-dependent and… CONTINUE READING

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