Early vascular abnormalities and de novo nitrate tolerance in diabetes mellitus.

@article{McVeigh2002EarlyVA,
  title={Early vascular abnormalities and de novo nitrate tolerance in diabetes mellitus.},
  author={Gary E. McVeigh and David R. Morgan and Phoebe. Allen and Mark Trimble and Pamela L Hamilton and Lana Jayne Dixon and Bernard Silke and Johnnie R. Hayes},
  journal={Diabetes, obesity & metabolism},
  year={2002},
  volume={4 5},
  pages={
          336-41
        }
}
OBJECTIVE The haemodynamic consequence of altered mechanical wall properties in diabetes can impair the compliance characteristics or pulsatile function of arteries before changes in calibre or peripheral resistance become evident. We studied the sensitivity of pulsatile and steady-state haemodynamic variables in identifying vascular abnormalities and assessing arterial responsiveness to glyceryl trinitrate (GTN) in patients with diabetes, free from clinical complications of the disease… CONTINUE READING
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