Early treatment with a novel inhibitor of lipid peroxidation (LY341122) improves histopathological outcome after moderate fluid percussion brain injury in rats.

@article{Wada1999EarlyTW,
  title={Early treatment with a novel inhibitor of lipid peroxidation (LY341122) improves histopathological outcome after moderate fluid percussion brain injury in rats.},
  author={K Wada and Ofelia Furones Alonso and Raul Busto and Jill Ann Panetta and James A. Clemens and Myron D. Ginsberg and W. Dalton Dietrich},
  journal={Neurosurgery},
  year={1999},
  volume={45 3},
  pages={
          601-8
        }
}
OBJECTIVE Reactive oxygen species are thought to participate in the pathobiology of traumatic brain injury (TBI). This study determined whether treatment with LY341122, a potent inhibitor of lipid peroxidation and an antioxidant, would provide neuroprotection in a rat model of TBI. METHODS To investigate the efficacy of LY341122 in this parasagittal fluid percussion model (1.8-2.1 atm), the rats received oral administration of LY341122 (100 mg/kg) or vehicle 2 hours before and 4 hours after… 
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