Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years.

@article{Thompson2007EarlyTE,
  title={Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years.},
  author={W. Thompson and Cristofer S. Price and B. Goodson and D. Shay and P. Benson and V. Hinrichsen and E. Lewis and E. Eriksen and P. Ray and S. M. Marcy and John Dunn and L. Jackson and T. Lieu and S. Black and G. Stewart and E. Weintraub and R. Davis and F. Destefano},
  journal={The New England journal of medicine},
  year={2007},
  volume={357 13},
  pages={
          1281-92
        }
}
BACKGROUND It has been hypothesized that early exposure to thimerosal, a mercury-containing preservative used in vaccines and immune globulin preparations, is associated with neuropsychological deficits in children. METHODS We enrolled 1047 children between the ages of 7 and 10 years and administered standardized tests assessing 42 neuropsychological outcomes. (We did not assess autism-spectrum disorders.) Exposure to mercury from thimerosal was determined from computerized immunization… Expand
Neuropsychological Performance 10 Years After Immunization in Infancy With Thimerosal-Containing Vaccines
TLDR
The few associations found between thimerosal exposure and neuropsychological development might be attributable to chance, and the associations found were based on small differences in mean test scores, and their clinical relevance remains to be determined. Expand
Thimerosal exposure in early life and neuropsychological outcomes 7-10 years later.
TLDR
There was a small, but statistically significant association between early thimerosal exposure and the presence of tics in boys, but this finding should be interpreted with caution due to limitations in the measurement of tic levels and the limited biological plausibility regarding a causal relationship. Expand
CDC Finds No Link Between Thimerosal and Neuropsychological Problems in Children
TLDR
The NEJM paper is the third major study to negate allegations that exposure to mercury-containing vaccines or immune globulins caused neuropsychological problems in immunized children. Expand
Prenatal and Infant Exposure to Thimerosal From Vaccines and Immunoglobulins and Risk of Autism
TLDR
In the study of MCO members, prenatal and early-life exposure to ethylmercury from thimerosal-containing vaccines and immunoglobulin preparations was not related to increased risk of ASDs. Expand
Early exposure to thimerosal-containing vaccines and children’s cognitive development. A 9-year prospective birth cohort study in Poland
TLDR
TCV administration in early infancy did not affect children’s cognitive development and developmental test results in children exposed to TCVs up to the 6th month of life also did not depend on thimerosal dose. Expand
Low-level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice.
TLDR
The present results do not indicate pervasive developmental neurotoxicity following vaccine-levelThimerosal injections in SJL mice, and provide little if any support for the hypothesis that thimerosal exposure contributes to the etiology of neurodevelopmental disorders. Expand
Methodological Issues and Evidence of Malfeasance in Research Purporting to Show Thimerosal in Vaccines Is Safe
TLDR
The United States Centers for Disease Control and Prevention states that Thimerosal is safe and there is “no relationship between [T]himerosal[-]containing vaccines and autism rates in children,” which is puzzling because, in a study conducted directly by CDC epidemiologists, a 7.6-fold increased risk of autism from exposure toThimerosal during infancy was found. Expand
The risk of neurodevelopmental disorders following Thimerosal-containing Hib vaccine in comparison to Thimerosal-free Hib vaccine administered from 1995 to 1999 in the United States.
TLDR
Suggestible evidence of an association between Thimerosal and neurodevelopmental outcomes is provided and support is provided for carrying out additional well-designed studies examining the association betweenThimerosal-containing vaccines and a wide range of neuro developmental outcomes. Expand
Cord Blood Mercury and Early Child Development: Effects of the World Trade Center
  • J. Dórea
  • Medicine
  • Environmental health perspectives
  • 2009
TLDR
Performance end points such as PDI and VFIQS could be affected by many intervening variables such as breast-feeding (and co-exposure to other toxic substances during brain growth and functional differentiation); these variables act mostly on the outcome, not necessarily on the level of Hg exposure. Expand
On-time Vaccine Receipt in the First Year Does Not Adversely Affect Neuropsychological Outcomes
TLDR
Timely vaccination during infancy has no adverse effect on neuropsychological outcomes 7 to 10 years later, and these data may reassure parents who are concerned that children receive too many vaccines too soon. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 44 REFERENCES
Thimerosal Exposure in Infants and Developmental Disorders: A Prospective Cohort Study in the United Kingdom Does Not Support a Causal Association
TLDR
A large United Kingdom population–based cohort study on childhood health and development could find no convincing evidence that early exposure to thimerosal had any deleterious effect on neurologic or psychological outcome. Expand
Thimerosal Exposure in Infants and Developmental Disorders: A Retrospective Cohort Study in the United Kingdom Does Not Support a Causal Association
TLDR
With the possible exception of tics, there was no evidence that thimerosal exposure via DTP/DT vaccines causes neurodevelopmental disorders. Expand
Methylmercury exposure biomarkers as indicators of neurotoxicity in children aged 7 years.
The mercury concentration in blood or scalp hair has been widely used as a biomarker for methylmercury exposure. Because of the increased risks associated with exposures during prenatal and earlyExpand
An assessment of thimerosal use in childhood vaccines.
TLDR
No evidence of harm caused by doses of thimerosal in vaccines, except for local hypersensitivity reactions is revealed, however, some infants may be exposed to cumulative levels of mercury during the first 6 months of life that exceed EPA recommendations. Expand
Neurotoxic effects of postnatal thimerosal are mouse strain dependent
TLDR
It is hypothesized that autoimmune propensity influences outcomes in mice following thimerosal challenges that mimic routine childhood immunizations, and these findings implicate genetic influences and provide a model for investigatingThimerosal-related neurotoxicity. Expand
Safety of thimerosal-containing vaccines: a two-phased study of computerized health maintenance organization databases.
TLDR
No consistent significant associations were found between TCVs and neuro developmental outcomes and studies with uniform neurodevelopmental assessments of children with a range of cumulative thimerosal exposures are needed. Expand
Comparison of Blood and Brain Mercury Levels in Infant Monkeys Exposed to Methylmercury or Vaccines Containing Thimerosal
TLDR
The results indicate that MeHg is not a suitable reference for risk assessment from exposure to thimerosal-derived Hg, and knowledge of the toxicokinetics and developmental toxicity ofThimerosal is needed to afford a meaningful assessment of the developmental effects of thimerosa-containing vaccines. Expand
Influence of Prenatal Mercury Exposure Upon Scholastic and Psychological Test Performance: Benchmark Analysis of a New Zealand Cohort
TLDR
BMD calculations and additional regression analyses of data from a study in which scores from 26 scholastic and psychological tests administered to 237 6- and 7-year-old New Zealand children were correlated with the mercury concentration in their mothers' hair during pregnancy do not find significant associations between mercury and children's test scores. Expand
Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles Child Development Study.
TLDR
In the population studied, consumption of a diet high in ocean fish appears to pose no threat to developmental outcomes through 66 months of age. Expand
Mercury concentrations and metabolism in infants receiving vaccines containing thiomersal: a descriptive study
TLDR
Administration of vaccines containing thiomersal does not seem to raise blood concentrations of mercury above safe values in infants, and ethylmercury seems to be eliminated from blood rapidly via the stools after parenteral administration of th iomersal in vaccines. Expand
...
1
2
3
4
5
...