Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease.

Abstract

Investigations of synaptic transmission and plasticity in mouse models of Huntington's disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease indicators. Similarly, recent human studies reveal synaptic dysfunction decades before predicted clinical diagnosis in HD gene carriers. These studies guide premanifest tracking of… (More)
DOI: 10.1016/j.tins.2010.08.002

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