Early stopping of aerospace medical trials: application of sequential principles.

Abstract

A two-period, crossover trial was conducted in the hypobaric chamber on human subjects to compare the influence of inflight exercise (experimental) and restricted activity (control) on altitude decompression sickness (DCS) during simulated extravehicular activities. Out of 39 pairs (total of 78 exposures), 4 cases of DCS occurred under control and 5… (More)

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Cite this paper

@article{Kumar1994EarlySO, title={Early stopping of aerospace medical trials: application of sequential principles.}, author={K. S. M. V. Kumar and Matthew Powell and James M. Waligora}, journal={Journal of clinical pharmacology}, year={1994}, volume={34 6}, pages={596-8} }