Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major.

@article{Smith1997EarlySI,
  title={Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major.},
  author={Terry K. Smith and Fiona C Milne and Davinder Kumar Sharma and A. Crossman and John S Brimacombe and Michael A J Ferguson},
  journal={The Biochemical journal},
  year={1997},
  volume={326 ( Pt 2)},
  pages={393-400}
}
A cell-free system based on washed Leishmania major membranes was labelled with GDP-[3H]Man in the presence of synthetic glucosaminyl-phosphatidylinositol (GlcN-PI) and N-acetylglucosaminyl-phosphatidylinositol (GlcNAc-PI). In both cases, the major radiolabelled products were Man alpha 1-4GlcN alpha 1-6myo-inositol1-HPO4- (sn-1, 2-dipalmitoylglycerol) and Man alpha 1-4GlcN alpha 1-6myo-inositol1-HPO4- (sn-1-palmitoyl-2-lyso-glycerol), to which an additional d-mannose residue was added when a… CONTINUE READING

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