Early stem cell transplantation for refractory acute leukemia after salvage therapy with high-dose etoposide and cyclophosphamide.

@article{Johny2006EarlySC,
  title={Early stem cell transplantation for refractory acute leukemia after salvage therapy with high-dose etoposide and cyclophosphamide.},
  author={Asha Johny and Kevin W. Song and Stephen H. Nantel and Julye C. Lavoie and Cynthia L. Toze and Donna Hogge and Donna L. Forrest and Heather J. Sutherland and Alan Le and Janet Y Nitta and Michael J. Barnett and Clayton O. Smith and John D. Shepherd and Thomas J. Nevill},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2006},
  volume={12 4},
  pages={
          480-9
        }
}
Primary refractory acute leukemia (AL) has a poor prognosis, although some patients can be salvaged with allogeneic stem cell transplantation (SCT). Induction of complete remission (CR) with conventional chemotherapy before SCT may improve outcome in this patient population. Between March 1991 and October 2003, 59 adults with primary refractory AL were treated with continuous-infusion etoposide (VP) 2.4 to 3.0 g/m(2) followed by cyclophosphamide (Cy) 6.0-7.2 g/m(2) intravenously over 3 to 4… CONTINUE READING

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