Early stages in the mechanism of action of glucocorticoids on human platelets. Effect of hydrocortisone on platelet aggregation

@article{Sergeev1997EarlySI,
  title={Early stages in the mechanism of action of glucocorticoids on human platelets. Effect of hydrocortisone on platelet aggregation},
  author={Pavel Sergeev and Alexander S Dukhanin and Farida Gubaeva},
  journal={Bulletin of Experimental Biology and Medicine},
  year={1997},
  volume={123},
  pages={46-48}
}
Hydrocortisone (1–10 µM) has no effect on spontaneous platelet aggregation and induces a 5–10-sec latency after platelet activation with 1 µM ADP. Hydrocortisone inhibits collagen-induced platelet aggregation; this effect is blocked by excess of progesterone. Hydrocortisone potentiates the effect of adenosine on disaggregation: in the absence of the hormone IC50 for adenosine is 2.5 µM, while in the presence of 3 and 10 µM hydrocortisone it drops to 1.7 and 0.4 µM, respectively. 

References

Publications referenced by this paper.

Receptor Mechanisms of the Glucocorticoid Effect [in Russian

  • P. P. Golikov, in
  • Moscow
  • 1988
1 Excerpt

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