Early stage vision in schizophrenia and schizotypal personality disorder

  title={Early stage vision in schizophrenia and schizotypal personality disorder},
  author={Brian F. O’Donnell and Andrew W. Bismark and William P. Hetrick and Misty Bodkins and Jenifer L. Vohs and A. Shekhar},
  journal={Schizophrenia Research},

Deficient visual sensitivity in schizotypal personality disorder

Visual contrast sensitivity in adults with schizophrenia and relatives not affected

The results showed changes in the visual mechanisms that process vertical sine-wave gratings related the schizophrenia, and that the visual CS for participants with schizophrenia was lower than those of adults without schizophrenia and the non-affected relatives.

Diminished parietal cortex activity associated with poor motion direction discrimination performance in schizophrenia.

It is suggested that abnormalities in later stages of motion-processing mechanisms, perhaps beyond extrastriate cortex, may account for behavioral deviations among schizophrenia subjects.

Early-stage visual processing deficits in schizophrenia

Understanding the nature of sensory processing deficits may provide insight into mechanisms of pathology in schizophrenia, such as N-methyl-D-aspartate dysfunction or impaired signal amplification, and could lead to treatment strategies including sensory processing rehabilitation that may improve outcome.

Patients with schizophrenia show deficits on spatial frequency doubling

Neural response to the second stimulus associated with poor speed discrimination performance in schizophrenia.

The findings indicate that the neural correlates of poor motion analysis in SZ may not be an early visual analysis abnormality but a problem with efficient use of speed information later in cognitive processing.

Visual perception in prediagnostic and early stage Huntington's disease

It is suggested that early stage HD disrupts visual functions associated with the magnocellular pathway, and changes are only observed in individuals diagnosed with HD or who are in the more symptomatic stages of prediagnostic HD.



Visual perception and working memory in schizotypal personality disorder.

Early-stage vision and working memory data suggest that subjects with schizotypal personality disorder, unlike patients affected by schizophrenia, have relatively intact visual perception.

Motion perception in schizophrenia.

The discrimination of small velocity differences is impaired in a subgroup of patients with schizophrenia, and both motion signals and the brain regions responsible for processing motion signals are implicated in the generation of smooth pursuit.

Impaired detection of visual motion in schizophrenia patients

  • C. Li
  • Psychology, Medicine
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2002

Psychometrically matched visual-processing tasks in schizophrenia spectrum disorders.

Evidence is provided of differential deficits in visual processing in schizophrenia that appear to be dependent on the temporal characteristics of the tasks.

Cognitive functions in schizotypal personality disorder

Spatiotemporal visual processing in schizophrenia.

The results suggest that the hypodopaminergic state induced by antipsychotic medication may produce parkinsonian visual impairments in schizophrenia patients.

Early-stage visual processing and cortical amplification deficits in schizophrenia.

These findings confirm the existence of early-stage visual processing dysfunction in schizophrenia and provide the first evidence that such deficits are due to decreased nonlinear signal amplification, consistent with glutamatergic theories.

Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit.

It is reported that the motion discrimination deficit, which occurs in both schizophrenic patients and in their first-degree relatives, involves a failure of velocity detection, which appears when judging intermediate target velocities and is associated with sluggish initiation of smooth pursuit.