Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002.

@article{Naito2003EarlySI,
  title={Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002.},
  author={Atsuhiko Thomas Naito and Aki Tominaga and Masahito Oyamada and Yumiko Oyamada and Isao Shiraishi and Koshiro Monzen and Issei Komuro and Tetsuro Takamatsu},
  journal={Experimental cell research},
  year={2003},
  volume={291 1},
  pages={
          56-69
        }
}
Inhibition of phosphatidylinositol 3-kinase (PI3-kinase) has been reported to block cardiomyocyte differentiation. However, at which stage PI3-kinase plays this important role and what its molecular targets are remain unknown. To answer these questions, we induced cardiomyocyte differentiation of P19CL6 mouse embryonal carcinoma cells and investigated the activation of PI3-kinase by analyzing phospho-Akt. We also treated P19CL6 cells with the PI3-kinase-specific inhibitor LY294002 either… CONTINUE READING
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