Early spread of scrapie from the gastrointestinal tract to the central nervous system involves autonomic fibers of the splanchnic and vagus nerves.

@article{McBride2001EarlySO,
  title={Early spread of scrapie from the gastrointestinal tract to the central nervous system involves autonomic fibers of the splanchnic and vagus nerves.},
  author={Patricia A. McBride and Walter J. Schulz-Schaeffer and Mary W. Donaldson and Moira Bruce and Heino Diringer and Hans A. Kretzschmar and Michael Beekes},
  journal={Journal of virology},
  year={2001},
  volume={75 19},
  pages={9320-7}
}
Although the ultimate target of infection is the central nervous system (CNS), there is evidence that the enteric nervous system (ENS) and the peripheral nervous system (PNS) are involved in the pathogenesis of orally communicated transmissible spongiform encephalopathies. In several peripherally challenged rodent models of scrapie, spread of infectious agent to the brain and spinal cord shows a pattern consistent with propagation along nerves supplying the viscera. We used immunocytochemistry… CONTINUE READING
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