Early signal transduction by the antigen receptor without commitment to T cell activation.

@article{Goldsmith1988EarlyST,
  title={Early signal transduction by the antigen receptor without commitment to T cell activation.},
  author={Mark Goldsmith and Arthur Weiss},
  journal={Science},
  year={1988},
  volume={240 4855},
  pages={1029-31}
}
The T lymphocyte antigen-receptor complex mediates antigen-specific cell activation, at least in part, through the production of inositolphospholipid-derived second messengers. Little is known about how second messenger events, typically measured within minutes of ligand binding, eventually lead to distal biologic responses such as expression of lymphokine genes. Several monoclonal antibodies directed against the receptor complex were tested for their ability to elicit transmembrane signaling… CONTINUE READING