Early-senescing human skin fibroblasts do not demonstrate accelerated telomere shortening.

  title={Early-senescing human skin fibroblasts do not demonstrate accelerated telomere shortening.},
  author={Marina Ferenac and Denis Polan{\vc}ec and Miljenko Huzak and Olivia Pereira-smith and Ivica Rubelj},
  journal={The journals of gerontology. Series A, Biological sciences and medical sciences},
  volume={60 7},
  • M. Ferenac, D. Polančec, I. Rubelj
  • Published 1 July 2005
  • Biology, Medicine
  • The journals of gerontology. Series A, Biological sciences and medical sciences
Most normal mammalian cell lines demonstrate limited growth capacity due to the gradual accumulation of senescent cells in the culture. Senescent cells appear initially at a low incidence, but with increasing frequency as the culture accumulates more divisions. Because it has been suggested that senescence is regulated by telomere shortening in human cells, we compared the telomere lengths of the subpopulation of senescent cells, present in presenescent cultures, with those of young cells… 

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