Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

  title={Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis},
  author={Yasser Iturria-Medina and Roberto C. Sotero and Pieter J. Toussaint and J. M. Mateos-P{\'e}rez and Alan C. Evans and Michael W Weiner and Paul S. Aisen and Ronald J. Petersen and Clifford R. Jack and William J. Jagust and Ronald C. Petersen and Arthur W. Toga and Laurel A. Beckett and Robert C Green and Andrew J. Saykin and John C. Morris and Leslie M. Shaw and Zaven S. Khachaturian and Greg Sorensen and Lewis H. Kuller and Marc Raichle and Steven Timothy Paul and Peter Ho Davies and Howard M. Fillit and Franz Hefti and Davie Holtzman and M. Marcel Mesulam and William Z. Potter and Peter J. Snyder and Adam Frederick Schwartz and Tom Montine and Ronald G. Thomas and Michael Donohue and Sarah Walter and Devon Gessert and Tamie Miura Sather and Gus Jiminez and Danielle Harvey and Matthew A. Bernstein and Nick C. Fox and Paul M. Thompson and Norbert W. Schuff and Bret Borowski and Jeff L. Gunter and Matt Senjem and Prashanthi Vemuri and David T. W. Jones and Kejal Kantarci and Chad P. Ward and Robert A. Koeppe and Norm Foster and Eric M. Reiman and Kewei Chen and C. A. Mathis and Susan M. Landau and Nigel J. Cairns and Erin Householder and Lisa Taylor-Reinwald and Virginia M.-Y. Lee and Magdalena Korecka and Michal J. Figurski and Karen Shichman Crawford and Scott Neu and Tatiana M. Foroud and Steven G. Potkin and Li Shen and Kelley Faber and Sungeun Kim and Kwangsik Nho and Leon Thal and Neil S. Buckholtz and Marylyn Albert and Richard C. Frank and John K. Hsiao and Jeffrey A. Kaye and Joseph F. Quinn and Betty Lind and Raina Carter and Sara Dolen and Andrzej T. Galecki and Sonia Pawluczyk and Mauricio Beccera and Liberty Teodoro and Bryan M. Spann and James Brewer and Helen Vanderswag and Adam S. Fleisher and Judith L. Heidebrink and Joanne L. Lord and Sara S. Mason and Colleen S. Albers and David S. Knopman and Doralyn Rossmann and Rachelle Doody and Javier Villanueva-Meyer and Munir Chowdhury and Susan D. Rountree and Mimi Dang and Yaakov Stern and Lawrence Sterling Honig and Karen Lennox Bell and Beau M. Ances and Maria Dreux Carroll and Sue Leon and Mark A. Mintun and Stacy R. Schneider and Angela Oliver and Daniel C. Marson and Randall Dudley Griffith and David Glenn Clark and David Geldmacher and John C. Brockington and Erik D Roberson and Hillel T. Grossman and Effie M. Mitsis and Leyla de Toledo-Morrell and Raj C. Shah and Ranjan Duara and Daniel J. Varon and Maria T. Greig and Peggy Cochran Roberts and Marilyn S. Albert and Chiadi Onyike and Daniel D'Agostino and Stephanie A. Kielb and James E. Galvin and Brittany Cerbone and Christina A. Michel and Henry Rusinek and Mony J de Leon and Lidia Glodzik and Susan M De Santi and P. Murali Doraiswamy and Jeffrey R. Petrella and Terence Z. Wong and Steven E Arnold and Jason H. T. Karlawish and David A. Wolk and Charles D. Smith and Gregory A. Jicha and Randall Griffith and Partha Sinha and Elizabeth Oates and G. E. Conrad and Oscar L. Lopez and MaryAnn Oakley and Donna M. Simpson and Anton P. Porsteinsson and Bonnie S. Goldstein and Kim Martin and Kelly M. Makino and M. Saleem Ismail and Connie Brand and Ruth A. Mulnard and Gaby T. Thai and Catherine Mc-Adams-Ortiz and Kyle Richard Womack and D. T. Mathews and Mary Quiceno and Ramon Diaz-Arrastia and Richard Vern King and Myron Weiner and Kristen Martin-Cook and Michael Devous and Allan I. Levey and James J Lah and Janet S. Cellar and Jeffrey M. Burns and Heather D. S. Anderson and Russell H Swerdlow and Liana G. Apostolova and Kathleen D. Tingus and Ellen Woo and Daniel H. S. Silverman and P. o H Lu and George Bartzokis and Neill R. Graff-Radford and Francine C. Parfitt and Tracy Kendall and Heather Beth Johnson and Martin R. Farlow and AnnMarie Hake and Brandy R. Matthews and Scott Herring and Cynthia Hunt and Christopher H. van Dyck and Richard E. Carson and Martha G Macavoy and Howard Chertkow and Howard Bergman and Chris Hosein and Sandra Elizabeth Black and Bojana Stefanovic and Curtis Caldwell and Ging-Yuek R Hsiung and Howard J Feldman and Benita Mudge and Michele Assaly and Andrew Kertesz and J. Kevin Rogers and C Bernick and Daniel Silverman and Diana R. Kerwin and Kristine Lipowski and Chuang-Kuo Wu and Nancy Rae Johnson and Carl H. Sadowsky and Walter F. Martinez and Teresa Berdugo Villena and Raymond Scott Turner and Kathleen S. Johnson and Brigid A. Reynolds and Reisa A. Sperling and Keith A. Johnson and Gad A Marshall and Meghan Frey and Barton Lane and Allyson Rosen and Jared Tinklenberg and Marwan N. Sabbagh and Christine Belden and Sandra A. Jacobson and Sherye A. Sirrel and Antonio Felicioli and Ronald J. Killiany and Andrew E. Budson and Alexander Norbash and Patricia Lynn Johnson and Joanne S. Allard and Alan M. Lerner and Paula J. Ogrocki and Leon Hudson and Evan Fletcher and O. B. Carmichael and John M. Olichney and Charles S. Decarli and Smita D. Kittur and Michael Borrie and T-Y Lee and Rob Bartha and Sterling K. Johnson and Sanjay Asthana and C. M. Gilbert. Carlsson and Adrian Preda and Dana Nguyen and Pierre N. Tariot and Stephanie Owen Reeder and Vernice Bates and Horacio A Capote and Michelle M Rainka and Douglas W Scharre and Maria Kataki and Anahita Adeli and Earl A. Zimmerman and Dzintra F Celmins and Alice D. Brown and Godfrey D. Pearlson and Karen L. Blank and Karen Charlotte Anderson and Robert B. Santulli and Tamar J. Kitzmiller and Eben S. Schwartz and Kaycee M Sink and Jeff D. Williamson and Pankaj Kumar Garg and Franklin S Watkins and Brian R. Ott and Henry Querfurth and Geoffrey N. Tremont and Stephen P. Salloway and P. E. Malloy and Stephen Correia and Howard Jeffrey Rosen and Bruce L. Miller and Jacobo E. Mintzer and Kenneth Spicer and David F. Bachman and Elizabether Finger and Stephen Pasternak and Irina Rachinsky and Dick J. Drost and Nunzio Pomara and Raymundo T. Hernando and Antero Sarrael and Susan K. Schultz and Laura L Boles Ponto and Hyungsub Shim and Karen Elizabeth Smith and Norman Relkin and Gloria Chaing and Lisa Raudin and Amanda Tweedie Smith and Kristin Fargher and Balebail Ashok Raj and Thomas Neylan and Jordan Grafman and Melissa Davis and Rosemary Morrison and Jacqueline Hayes and Shannon Finley and Karl E. Friedl and Debra A. Fleischman and Konstantinos Arfanakis and Olutayo James and Dino Massoglia and J. Jay Fruehling and Sandra J. Harding and E. R. Peskind and Eric C. Petrie and Gail Li and Jerome A Yesavage and Joy L. Taylor and Ansgar J. Furst},
  booktitle={Nature communications},
Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer's Disease… CONTINUE READING

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