Early restriction of the human antibody repertoire.

@article{Schroeder1987EarlyRO,
  title={Early restriction of the human antibody repertoire.},
  author={Harry W. Schroeder and J L Hillson and Roger M. Perlmutter},
  journal={Science},
  year={1987},
  volume={238 4828},
  pages={791-3}
}
Diversification of the antibody repertoire in mammals results from a series of apparently random somatically propagated gene rearrangement and mutational events. Nevertheless, it is well known that the adult repertoire of antibody specificities is acquired in a developmentally programmed fashion. As previously shown, rearrangement of the gene segments encoding the heavy-chain variable regions (VH) of mouse antibodies is also developmentally ordered: the number of VH gene segments rearranged in… CONTINUE READING

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