Early responses in mitogenic signaling, bombesin induced protein phosphorylations in Swiss 3T3 cells.

@article{Lint1993EarlyRI,
  title={Early responses in mitogenic signaling, bombesin induced protein phosphorylations in Swiss 3T3 cells.},
  author={J. Van Lint and P. Agostinis and W. Merlevede and J. Vandenheede},
  journal={Advances in enzyme regulation},
  year={1993},
  volume={33},
  pages={
          143-55
        }
}
The amphibian tetradecapeptide bombesin as well as the bombesin-related mammalian peptides are potent mitogens for Swiss 3T3 cells. Other sole mitogens for Swiss 3T3 cells, such as PDGF and FGF, invariably signal through a tyrosine kinase receptor. The bombesin receptor has been cloned from Swiss 3T3 fibroblasts and was shown to be a member of the family of G-protein-linked neuropeptide receptors, whose sequence does not reveal a protein kinase domain. Upon binding to its receptor, bombesin… Expand

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