Early requirement for fgf8 function during hindbrain pattern formation in zebrafish.

@article{Wiellette2004EarlyRF,
  title={Early requirement for fgf8 function during hindbrain pattern formation in zebrafish.},
  author={Elizabeth L Wiellette and Hazel L. Sive},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2004},
  volume={229 2},
  pages={393-9}
}
Fibroblast growth factor (FGF) signaling is required for normal development of the vertebrate brain, including the isthmus and caudal regions of the hindbrain. Recent work in zebrafish has identified a requirement for the combination of fgf3 and fgf8 functions in specification of rhombomeres 5 and 6 (r5, r6), when evaluated at mid- and late somitogenesis stages. However, when examined earlier in development, during early somitogenesis stages, FGF8 alone is required to initiate r5 and r6… CONTINUE READING