Early requirement for B cells for development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice.

@article{BraleyMullen2000EarlyRF,
  title={Early requirement for B cells for development of spontaneous autoimmune thyroiditis in NOD.H-2h4 mice.},
  author={Helen Braley-Mullen and Shuo Yu},
  journal={Journal of immunology},
  year={2000},
  volume={165 12},
  pages={7262-9}
}
B cells are known to play an important role in the pathogenesis of several autoimmune diseases. NOD.H-2h4 mice develop spontaneous autoimmune thyroiditis (SAT) and anti-mouse thyroglobulin (MTg) autoantibodies, the levels of which correlate closely with the severity of thyroid lesions. NOD.H-2h4 mice genetically deficient in B cells (NOD.Kmu(null)) or rendered B cell-deficient by treatment from birth with anti-IgM develop minimal SAT. B cells were required some time in the first 4-6 wk after… CONTINUE READING
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CD41 T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools

  • N. Baumgarth, G. Jager, C. Ometa, L. A. Herzenberg
  • Proc. Natl. Acad. Sci. USA
  • 2000
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