Early replication of herpesviruses in naturally occurring frog tumors.

@article{Mckinnell1972EarlyRO,
  title={Early replication of herpesviruses in naturally occurring frog tumors.},
  author={R G Mckinnell and V L Ellis and D C Dapkus and L M Steven},
  journal={Cancer research},
  year={1972},
  volume={32 8},
  pages={1729-33}
}
Renal adenocarcinomas of the leopard frog, Rana pipiens, collected in Kandiyohi County, Minn., were fixed for electron microscopy prior to and 4, 7, 13, and 16 days after the entry of host frogs into lakes for overwintering. Fifteen tumors were studied. No herpesviruses were detected in 4 tumors of prehibernating frogs. Two tumors of frogs autopsied on Day 4 of overwintering did not show viruses. Mature herpesviruses were observed in 2 tumors of frogs that had been in lake water for 7 days. The… CONTINUE READING