Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study.

@article{Beeri2007EarlyRO,
  title={Early repair of moderate ischemic mitral regurgitation reverses left ventricular remodeling: a functional and molecular study.},
  author={Ronen Beeri and Chaim Yosefy and J. Luis Guerrero and Suzan Abedat and Mark D. Handschumacher and Robert E. Stroud and Suzanne M Sullivan and Miguel Chaput and Dan Gilon and Gus J. Vlahakes and Francis G. Spinale and Roger J. Hajjar and Robert A. Levine},
  journal={Circulation},
  year={2007},
  volume={116 11 Suppl},
  pages={I288-93}
}
BACKGROUND Mitral regurgitation (MR) doubles postmyocardial infarction (MI) mortality. We have shown that moderate MR augments remodeling in an apical MI model (no intrinsic MR) with independent left ventricle-to-left atrial MR-type flow. We hypothesized that repairing moderate MR 1 month after MI reverses this remodeling. METHODS AND RESULTS Anteroapical MIs were created in 18 sheep, and a left ventricle-to-left atrial shunt implanted in 12 (regurgitant fraction, 30%). Six sheep had the… CONTINUE READING