Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans.

@article{Cohen2010EarlyRO,
  title={Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans.},
  author={Mitchell Jay Cohen and Michel Carl{\`e}s and Karim Brohi and Carolyn S. Calfee and Pamela Rahn and Mariah S Call and Brian B Chesebro and Michael A. West and J F Pittet},
  journal={The Journal of trauma},
  year={2010},
  volume={68 6},
  pages={1273-8}
}
BACKGROUND The receptor for advanced glycation endproducts (RAGE) recognizes a variety of ligands that play an important role in the posttraumatic inflammatory response. However, whether soluble RAGE (sRAGE) is released early after trauma hemorrhage in humans and whether such a release is associated with the development of an inflammatory response and coagulopathy is not known and therefore constitutes the aim of this study. METHODS One hundred sixty-eight patients were studied as part of a… CONTINUE READING
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