Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein.

@article{Hunt2002EarlyRO,
  title={Early recurrence of benign meningioma correlates with expression of mini-chromosome maintenance-2 protein.},
  author={David P J Hunt and Alex Freeman and Lesley S. Morris and Neil G. Burnet and Kate Bird and Trevor W Davies and Ronald A. Laskey and Nick Coleman},
  journal={British journal of neurosurgery},
  year={2002},
  volume={16 1},
  pages={10-5}
}
We have investigated the potential utility of monoclonal antibodies against mini-chromosome maintenance-2 protein (Mcm2) in predicting meningioma recurrence. MCM proteins are members of the DNA-binding prereplicative complex and are essential for eukaryotic DNA replication. They are present throughout the cell cycle, but are down-regulated in quiescence and cell differentiation, making them specific markers of proliferating cells. We analysed 10 benign meningiomas that subsequently recurred… CONTINUE READING

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