Early protective effects of tiotropium bromide in patients with airways hyperresponsiveness.

@article{Terzano2004EarlyPE,
  title={Early protective effects of tiotropium bromide in patients with airways hyperresponsiveness.},
  author={Claudio Terzano and Angelo Petroianni and Alberto Ricci and Loris D'Antoni and Luigi Allegra},
  journal={European review for medical and pharmacological sciences},
  year={2004},
  volume={8 6},
  pages={259-64}
}
Tiotropium is an anticholinergic drug for Chronic Obstructive Pulmonary Disease (COPD) patients, with a peak bronchodilator effect observed after 1.5 to 2 hours and a long duration of action. The aim of our study was to quantify the early protection of a single dose of inhaled tiotropium against methacholine-induced bronchoconstriction in asthmatic patients with airway hyperresponsiveness. Ten subjects (7M, 3F), with history of asthma and a baseline FEV(1) (Forced Expiratory Volume 1 sec) > 80… CONTINUE READING

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