Early production of type I interferon during West Nile virus infection: role for lymphoid tissues in IRF3-independent interferon production.

@article{Bourne2007EarlyPO,
  title={Early production of type I interferon during West Nile virus infection: role for lymphoid tissues in IRF3-independent interferon production.},
  author={Nigel Bourne and Frank Scholle and Maria Carlan Silva and Shannan L. Rossi and Nathan Dewsbury and Barbara M. Judy and Juliana B de Aguiar and Megan A. Le{\'o}n and D. Mark Estes and Rafik Fayzulin and Peter W. Mason},
  journal={Journal of virology},
  year={2007},
  volume={81 17},
  pages={9100-8}
}
Infection of cells with flaviviruses in vitro is reduced by pretreatment with small amounts of type I interferon (IFN-alpha/beta). Similarly, pretreatment of animals with IFN and experiments using mice defective in IFN signaling have indicated a role for IFN in controlling flavivirus disease in vivo. These data, along with findings that flavivirus-infected cells block IFN signaling, suggest that flavivirus infection can trigger an IFN response. To investigate IFN gene induction by the very… CONTINUE READING

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