Early production of tumor necrosis factor-alpha by Gr-1 cells and its role in the host defense to pneumococcal infection in lungs.

@article{Hatta2010EarlyPO,
  title={Early production of tumor necrosis factor-alpha by Gr-1 cells and its role in the host defense to pneumococcal infection in lungs.},
  author={Masumitsu Hatta and Natsuo Yamamoto and Akiko Miyazato and Naoto Ishii and Kiwamu Nakamura and Ken Inden and Tetsuji Aoyagi and Hiroyuki Kunishima and Yoichi Hirakata and Kazuo Suzuki and Mitsuo Kaku and Kazuyoshi Kawakami},
  journal={FEMS immunology and medical microbiology},
  year={2010},
  volume={58 2},
  pages={182-92}
}
In this study, we elucidated the role of tumor necrosis factor (TNF)-alpha in the host defense to pulmonary infection with Streptococcus pneumoniae and defined the cellular source of this cytokine at an early stage of infection. Administration of anti-TNF-alpha monoclonal antibody (mAb) resulted in the reduced accumulation of neutrophils in bronchoalveolar lavage fluids (BALFs) and severe exacerbation of this infection. In a flow cytometric analysis, the intracellular expression of TNF-alpha… CONTINUE READING