Early primary cytomegalovirus infection in pregnancy: maternal hyperimmunoglobulin therapy improves outcomes among infants at 1 year of age.

@article{Visentin2012EarlyPC,
  title={Early primary cytomegalovirus infection in pregnancy: maternal hyperimmunoglobulin therapy improves outcomes among infants at 1 year of age.},
  author={Silvia Visentin and Renzo Manara and Laura Milanese and Anna Da Roit and Gabriella Forner and Eleonora Salviato and Valentina Citton and Fioretta Marciani Magno and Eva Orzan and Carla Morando and Riccardo Cusinato and Carlo Mengoli and Giorgio Pal{\`u} and M. Ermani and Roberto Rinaldi and Erich Cosmi and Nadia Gussetti},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2012},
  volume={55 4},
  pages={497-503}
}
BACKGROUND Primary cytomegalovirus (CMV) infection during pregnancy is the leading infectious cause of congenital neurological disabilities. Early CMV infection carries a higher risk of adverse neonatal outcome (sensorineural hearing loss or neurological deficits). Intravenous hyperimmunoglobulin (HIG) therapy seems to be promising, but its efficacy needs further investigation. METHODS Since 2002, we have enrolled consecutively all pregnant women with early (ie, before gestational week 17… CONTINUE READING
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