Early preservation of effector functions followed by eventual T cell memory depletion: a model for the delayed onset of the effect of thiopurines.

@article{BenHorin2009EarlyPO,
  title={Early preservation of effector functions followed by eventual T cell memory depletion: a model for the delayed onset of the effect of thiopurines.},
  author={Shomron Ben-Horin and Ido Goldstein and E Fudim and Odile Picard and Z. Yerushalmi and Iris Barshack and I Bank and Y. Goldschmid and Shimon Bar Meir and Lloyd Hitoshi Mayer and Yehuda Chowers},
  journal={Gut},
  year={2009},
  volume={58 3},
  pages={
          396-403
        }
}
OBJECTIVE The onset of the effect of thiopurines is delayed for several months. The aim of this study was to investigate immune mechanisms for this delay. METHODS The effects of thiopurines on human peripheral blood T cells and on lamina propria lymphocytes were investigated for apoptosis induction by Annexin V/propidium iodide (PI) and for cytokine secretion by intracellular staining and ELISA assays. To investigate the mechanism of the effect of thiopurines in vivo, Balb/C mice were co… CONTINUE READING

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