Early posttranslational modifications of the three neurofilament subunits in mouse retinal ganglion cells: neuronal sites and time course in relation to subunit polymerization and axonal transport.

@article{Nixon1989EarlyPM,
  title={Early posttranslational modifications of the three neurofilament subunits in mouse retinal ganglion cells: neuronal sites and time course in relation to subunit polymerization and axonal transport.},
  author={Ralph A. Nixon and Susan E. Lewis and Doris Dahl and Charles A. Marotta and Ursula C. Drager},
  journal={Brain research. Molecular brain research},
  year={1989},
  volume={5 2},
  pages={93-108}
}
We have characterized stages in the posttranslational processing of the three neurofilament subunits, High (NF-H), Middle (NF-M), and Low (NF-L), in retinal ganglion cells in vivo during the interval between synthesis in cell bodies within the retina and appearance of these polypeptides in axons at the level of the optic nerve (optic axons). Neurofilament proteins pulse-labeled by injecting mice intravitreally with [35S]methionine or [32P]orthophosphate, were isolated from Triton-soluble and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Brain-derived neurotrophic factor and TrkB modulate visual experience-dependent refinement of neuronal pathways in retina.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2007
View 3 Excerpts
Highly Influenced

Neurofilaments at a glance.

Journal of cell science • 2012
View 4 Excerpts

Similar Papers

Loading similar papers…