Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia.

@article{Benders2006EarlyPA,
  title={Early postnatal allopurinol does not improve short term outcome after severe birth asphyxia.},
  author={M J N L Benders and Arend F Bos and Carin M. A. Rademaker and Monique Rijken and Helen L Torrance and Floris Groenendaal and Frank van Bel},
  journal={Archives of disease in childhood. Fetal and neonatal edition},
  year={2006},
  volume={91 3},
  pages={F163-5}
}
OBJECTIVE To investigate whether postnatal allopurinol would reduce free radical induced reperfusion/reoxygenation injury of the brain in severely asphyxiated neonates. METHOD In an interim analysis of a randomised, double blind, placebo controlled study, 32 severely asphyxiated infants were given allopurinol or a vehicle within four hours of birth. RESULTS The analysis showed an unaltered (high) mortality and morbidity in the infants treated with allopurinol. CONCLUSION Allopurinol… CONTINUE READING
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