Early postnatal administration of 5,7-DHT: effects on serotonergic neurons and terminals.

@article{Towle1984EarlyPA,
  title={Early postnatal administration of 5,7-DHT: effects on serotonergic neurons and terminals.},
  author={Andrew C. Towle and George R. Breese and Robert A. Mueller and S F Coyle and Jean Lauder},
  journal={Brain research},
  year={1984},
  volume={310 1},
  pages={67-75}
}
Serotonergic neurons throughout the brain were destroyed by early postnatal treatment of rats with an intracisternal injection of 5,7-dihydroxytryptamine (5,7-DHT), as demonstrated with biochemical measurements of serotonin and immunocytochemical localization of serotonin-containing neurons. Using these methods, it was shown that approximately 75-98% of serotonergic neurons underwent cell death in rats which were treated on day 3. In contrast, intracisternal administration of 5,7-DHT in adult… CONTINUE READING

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