Early polyuria in the rat following single-dose cis-dichlorodiammineplatinum (II): effects on plasma vasopressin concentration and posterior pituitary function.


Central effects associated with DDP-induced early polyuria are described. Male Sprague-Dawley rats injected intraperitoneally with DDP (5 mg/kg) have a threefold increase in urine volume in the first 24 hr after treatment. This is accompanied by a corresponding decrease in Uosm but no decrease in renal function as indicated by serum creatinine or GFR… (More)


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